The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.

Western

Western blot analysis of ING5 in Jurkat and HepG2 lysates using ING5 antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human brain using ING5 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.